I have read many articles related to Wolfram syndrome. The most-read article is entitled "Neurodegeneration and diabetes: UK nationwide study of Wolfram (DIDMOAD) syndrome" describing the natural history of Wolfram syndrome. This article was written by Timothy Barrett, MB, BS (MD), PhD in 1995.
I read this paper over and over when I started working on Wolfram syndrome in 2002. I recommend that all the researchers in diabetes, neurodegeneration, and genetic diseases, read this article.