Some people say that it is not realistic to develop a novel therapy to stop the progression of eye manifestations in Wolfram syndrome. I don't agree. It is possible. If we can modulate ER stress in retinal cells, we can slow or stop the progression of optic nerve atrophy in Wolfram syndrome.
I have found a biotech company in Seattle that is developing novel therapeutics for "sight-threatening" eye diseases. If they can do it, we can do it.