My team's new initiative is to develop a "combination therapy" for Wolfram and Type 1 diabetes. What is a "combination therapy"? It is a therapy that uses more than one medication or modality. The advantage for this is that we can target different enzymes involved in the disease progression, which may increase our chance of stopping the progression. We may be able to decrease the dose of each drug, which reduces the risk of side effects. The challenge is that we don't know which combination is the best. It is almost like solving the puzzle, but we will keep on trying.
Thank you for reading this. I hope you have a wonderful Sunday.