I received another question regarding my blog of September 26, 2014.
How does MANF confer protection against ER stress-mediated cell death and stimulate proliferation of beta cells and neurons?
We are still looking for an answer. It seems like that MANF binds to another molecule in our cells and activate enzymes important for cell survival. So our strategy is to manipulate this process using a small molecule (i.e., a drug). This is aligned with our strategy #2.
Thank you for reading this blog. I hope you will have a wonderful day. Take care, Fumi Urano