As I mentioned in my previous blog, one of our new important projects is to make eyes cells from iPS cells of our patients with Wolfram syndrome. These iPS cells are originally generated from skin cells of our patients.
We have prepared necessary reagents and cells, and the differentiation process is ongoing (i.e., we are converting iPS cells from patients to eye cells). In several weeks, we will get the first results. These cells will be used for understanding the mechanisms of optic nerve dysfunction in Wolfram and testing the efficacy of candidate eye drugs. In the future, these cells could be used for replacing damaged eye cells.
I plan to keep you updated about our progress regularly.