Sunday, June 8, 2014

MANF, Wolfram, and Diabetes #6: Protecting remaining tissues

Yesterday, I articulated our strategy for protecting remaining beta cells and brain cells with MANF.
1. Inject recombinant MANF to patients.
2. Stabilize endogenous MANF
3. Activate a receptor for MANF

I feel that these are realistic plans. The same strategy has been applied to GLP-1, a molecule produced in our guts, and GLP-1 related drugs are widely and successfully used for patients with type 2 diabetes.
http://www.medscape.com/viewarticle/751632

We are currently focusing on "recombinant" MANF, and hope to expand our research in this area.