Strategies for developing a treatment for Wolfram

Our current strategies for developing a treatment for Wolfram are the following.

1. Inactivate molecules that play important roles in ER stress-mediated cell death.

2. Manipulate ER redox state (maintain oxidized ER) and ER calcium homeostasis (maintain calcium levels) under ER stress conditions.

We are looking for drugs that have the ability to inactivate cell death molecule and/or maintain ER calcium levels in Wolfram syndrome.