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A cure for Wolfram syndrome could lead to a cure for diabetes and blindness.

Sunday, April 13, 2014

MANF, Wolfram, and Diabetes-Part 2

An important article on MANF has been just published by a group in Europe. The article shows that MANF is essential for survival of pancreatic beta cells.

What is MANF?  As I mentioned in my previous blog, we discovered that MANF (mesencephalic astrocyte-derived neurotrophic factor) was secreted from pancreatic beta cells and neurons when their endoplasmic reticulum calcium was depleted. We also claimed that MANF could be a promising biomarker and therapeutic target for Wolfram and type 1 diabetes.

Why is this article important for us? This article supports our theory that MANF is an important therapeutic target for Wolfram and diabetes! I was really encouraged by this article. Currently, we are focusing on the clinical applications of MANF in Wolfram syndrome, diabetes, and other endoplasmic reticulum-related disorders. I hope we can bring you good news soon!