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A cure for Wolfram syndrome could lead to a cure for diabetes.

Sunday, April 13, 2014

MANF, Wolfram, and Diabetes-Part 2

An important article on MANF has been just published by a group in Europe. The article shows that MANF is essential for survival of pancreatic beta cells.
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00201-0

What is MANF?  As I mentioned in my previous blog, we discovered that MANF (mesencephalic astrocyte-derived neurotrophic factor) was secreted from pancreatic beta cells and neurons when their endoplasmic reticulum calcium was depleted. We also claimed that MANF could be a promising biomarker and therapeutic target for Wolfram and type 1 diabetes.
http://wolframsyndrome.blogspot.com/2014/01/manf-wolfram-and-diabetes-what-is-manf.html

Why is this article important for us? This article supports our theory that MANF is an important therapeutic target for Wolfram and diabetes! I was really encouraged by this article. Currently, we are focusing on the clinical applications of MANF in Wolfram syndrome, diabetes, and other endoplasmic reticulum-related disorders. I hope we can bring you good news soon!