Calcium might be a key to understand Wolfram syndrome

We have recently found a critical enzyme executing cell death in Wolfram syndrome. It seems like that activity of this enzyme is regulated by calcium. Based on our preliminary data, endoplasmic dysfunction creates a shunt between the endoplasmic reticulum and the cytosol, leading to calcium leakage into the cytosol. This may be a key event that can cause cell death. We are actively looking for drugs that can prevent this event.